Nutramedix Bromelain: proteolytic enzymes
Bromelain by NutraMedix contains proteolytic enzymes harvested from pineapple stems. Bromelain may help with proteolytic enzyme support, helping facilitate the body’s normal breakdown of unneeded proteins resulting from natural body processes. Bromelain may also help with joint health support, exercise support, and healthy inflammatory response support.
In addition to proteolytic enzymes, Bromelain by NutraMedix 60 caps bottle picture contains protease inhibitors, minerals, organic solvents, and organic acids. The proteolytic enzymes in bromelain help break down larger proteins into shorter peptides by hydrolyzing peptide bonds. This mechanism may support multiple facets of health. In vitro studies have shown that bromelain is highly bioavailable, attributed to its ability to bind to alpha1-antichymotrypsin and alpha2-macroglobulin in the blood.
The glycoprotein alpha-1-antichymotrypsin (AACT), a serine protease inhibitor, is mainly synthesized in the liver and then secreted into the blood and is involved in the acute phase response, inflammation, and proteolysis. The dysregulation of AACT and its glycosylation levels are associated with tumor progression and recurrence, and could be used as a biomarker for tumor monitoring. In this review, we summarized the expression level, glycosylation modification, and biological characteristics of AACT during inflammation, neurodegenerative or other elderly diseases, and tumorigenesis, as well as, focused on the biological roles of AACT in cancer.
Abstract
Glycosylation is one of the most important modifications of proteins and lipids, and cell surface glycoconjugates are thought to play important roles in a variety of biological functions including cell-cell and cell-substrate interactions, bacterial adhesion, cell immunogenicity and cell signaling. Alterations of glycosylation are observed in a number of inflammatory diseases. Pro-inflammatory cytokines have been shown to modulate cell surface glycosylation by regulating the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of glycan chains, inducing the expression of specific carbohydrate antigens at the cell surface that can be recognized by different types of lectins or by bacterial adhesins, contributing to the development of diseases. Glycosylation can also regulate biological functions of immune cells by recruiting leukocytes to inflammation sites with pro- or anti-inflammatory effects. Cell surface proteoglycans provide a large panel of binding sites for many mediators of inflammation, and regulate their bio-availability and functions.
Bromelain by NutraMedix 60 caps bottle rigorously follows current good manufacturing practices (cGMPs), as do our suppliers, including stringent ID testing, microbial testing, and heavy-metal testing. This testing is conducted on both the raw material and after encapsulation
This product and information have not been evaluated by the FDA It does not cure, prevent, treat or diagnose any disease.
